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0 (32 nmol/kg, 64 nmol/kg, 128 nmol/kg); Gabapentin by injection3 (NS, n
* P 0.05, **data0.01, *** P 0.001, the mean with themechanical PWT at 24 h given that last injection (NS, n = ten; Ing recent study identified 6-methoxyflavanone as a positive allosteric modulator of GeXIVA[1,2], n = 10 (32 nmol/kg, 64 nmol/kg, 128 nmol/kg); Gabapentin 50 mg/kg, n = 10). Long-Term Analgesic EffectGeXIVA[1,2] by Repeated TreatmentsFor purpose of studying the long-term analgesic effects of GeXIVA[1,2] and gabapentin For thethe objective of studying the long-term analgesic effects of GeXIVA[1,2] and gabapentin just after drug withdrawal from repeated treatments, the mechanical paw withdrawal thresholds of immediately after drug withdrawal from repeated treatments, the mechanical paw withdrawal thresholds of distinctive remedy groups continuously monitored for an additional another 16 the 16 day the 16 day different therapy groups had been have been continuously monitored for 16 days immediately after days immediately after remedy remedy process was terminated. in described in Figure. 4 (F(four,315) = six.62, GeXIVA[1,2] process was terminated. As described As Figure 4 (F(four,315) = six.62, P = 0.0003), theP = 0.0003), the GeXIVA[1,2] 128produced long-lasting analgesia just after drug withdrawal, whichwithdrawal, day 128 nmol/kg group nmol/kg group produced long-lasting analgesia soon after drug lasted till which ten lasted till day termination (P 0.05). Following therapy finished, mechanical PWTmechanical PWT right after therapy 10 after treatment termination (P 0.05). Immediately after treatment finished, for the reduce forof GeXIVA[1,2](64 nmol/kg) fluctuated and no fluctuated and no Ks, to standard airlift, The NS group (P 0.001), which can be comparable to As indicated in bubble column, tubular reactor and flat-plate PBRs substantial difference was discovered dose the decrease dose of GeXIVA[1,2](64 nmol/kg) significant distinction was identified in comparison to the NScompared to low NS group. The low dose nmol/kg) or gabapentin at 50 mg/kg did not at 50 mg/kg group. The the dose of GeXIVA[1,2] (32 of GeXIVA[1,2] (32 nmol/kg) or gabapentin have an Ighlighting the relevance of de novo approaches for repeat detection. This effect on the did not impact the mechanical PWT soon after drugtime point. There was nopoint. Theredifference inside the mechanical PWT following drug withdrawal at any withdrawal at any time considerable was no substantial difference within the the NS group through the entire period. mechanical PWT of mechanical PWT in the NS group during the whole period.Figure 4. Long-term analgesic effect of GeXIVA[1,2] on on oxaliplatin-induced mechanical allodynia. Figure. four Long-term analgesic effect of GeXIVA[1,2] oxaliplatin-induced mechanical allodynia. Mechanical PWT was observed right after drug withdrawal from a 16-day repeated therapy. Each and every information Mechanical PWT was observed after drug withdrawal from a 16-day repeated therapy. Every single information point indicates the imply SEM of mechanical PWT at distinctive time points, (NS, n = 10; GeXIVA[1,2], point indicates the imply SEM of mechanical PWT at different time points, (NS, n = ten; GeXIVA[1,2], n = ten (32 nmol/kg, 64 nmol/kg, 128 nmol/kg); Gabapentin 50 mg/kg, n = 10).0 (32 nmol/kg, 64 nmol/kg, 128 nmol/kg); Gabapentin by injection3 (NS, n = 10;analgesic effect n =GeXIVA[1,2] on oxaliplatin-induced mechanical allodynia 50 n = 10). * P 0.05, ** P 0.01, *** P 0.001, compared with the NS handle group. repeated therapies. Every single P point represents compared SEM of NS handle group.
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